An extensive exposition of this complex phenomenon is beyond the scope of this article (Rankin 2004). Inflammation and platelet activation are critical phenomena in the setting of acute coronary syndromes. Cell-to-cell communication molecules such as cytokines play an extremely important role in mediating the process of inflammation. The inflammatory response represents a complex biological and biochemical process involving cells of the immune system and a plethora of biological mediators. Three major events occur during the inflammatory response: the blood supply to the affected area is increased substantially, capillary permeability is increased, and leucocytes migrate from the capillary vessels into the surrounding interstitial spaces to the site of inflammation or injury. The inflammatory response may be triggered by mechanical injury, chemical toxins, and invasion by microorganisms, and hypersensitivity reactions. Secondly, inflammation occurs in living tissue, hence there is need for an adequate blood supply to the tissues in order to exhibit an inflammatory response. Infact, if injured tissue does not exhibit signs of inflammation this would be considered abnormal and wounds and infections would never heal without inflammation. First, that inflammation is a normal response and, as such, is expected to occur when tissue is damaged. It is important to emphasize two components of this definition. Inflammation is defined as the normal response of living tissue to injury or infection.
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